The Haptoglobin genotype predicts cardio-renal mortality in type 1 diabetes
نویسندگان
چکیده
منابع مشابه
Haptoglobin Genotype and Renal Function Decline in Type 1 Diabetes
OBJECTIVE Haptoglobin (Hp) binds free Hb, inhibiting Hb-induced oxidative damage. As oxidative stress has been associated with microvascular complications, we evaluated the relationship between Hp genotype and microalbuminuria, macroalbuminuria, end-stage renal disease (ESRD), and early renal function decline in type 1 diabetes. RESEARCH DESIGN AND METHODS Participants from the Epidemiology o...
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BACKGROUND We aimed to analyze the relationships between skin autofluorescence (SAF) and incident macrovascular events and renal impairment after 4 years of follow-up in patients with type 1 diabetes (T1D). METHODS Two hundred and forty-three patients (51.2 ± 16.7 years old) with T1D participated. SAF was measured by AGE-Reader-TM at inclusion. Macrovascular events (MVE), estimated glomerular...
متن کاملAdolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT)
BACKGROUND The prognosis for young people diagnosed with diabetes during childhood remains poor and this is mainly related to the long-term risk of developing vascular complications.Microalbuminuria identifies subjects at risk for diabetic nephropathy (DN) and cardiovascular disease (CVD). It is often detected in adolescence but is rarely treated before the age of 18 years, as at the end of pub...
متن کاملHaptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes
BACKGROUND Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis. METHODS CAC was measured three times in six years among 436 subjects with type 1 diabetes and 526 control subjects part...
متن کاملHaptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes.
OBJECTIVE Haptoglobin is a plasma protein that binds free hemoglobin, thereby inhibiting hemoglobin-induced oxidative damage. We investigated the association between the haptoglobin genotype and the incidence of coronary artery disease (CAD) in a cohort of individuals with childhood-onset type 1 diabetes. RESEARCH DESIGN AND METHODS Participants from the Epidemiology of Diabetes Complications...
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ژورنال
عنوان ژورنال: Journal of Diabetes and its Complications
سال: 2016
ISSN: 1056-8727
DOI: 10.1016/j.jdiacomp.2015.11.011